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Alcohol consumption and risk for venous thromboembolism: a meta-analysis of prospective studies

The resultant 11-hydroperoxyeicosatrienoic acid (11-HPETE) spontaneously degrades to 11-hydroperoxydienoic acid (11-HPODE) and the (Z)-non-3-enal, which is then catalytically converted to 4HNE by cytochrome p450 isozyme CYP2E6 (and others)

Effects were seen at extremely low concentrations (10 -12 to 10 -9 M), but higher concentrations actually inhibited growth demonstrating a precise dose-response relationship

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