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13 Moreover, we evaluated each parameter in five facial areas, including the forehead, nose, cheeks, temple, and under the eye

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Quality of included reports was scored using the Jadad composite scale,13 which assesses the description of randomization, blinding, and withdrawals in the reports.14 The quality scale ranges from 0 to 5 points with a low quality report of score 2 or less and a high quality report of score at least 3.15 All discrepancies were resolved after going back to the original source papers, by consensus and involvement of a third reviewer when necessary

This means that age-related greying might have a predetermined clock , and this clock might be based entirely on how many times melanocytes must divide, differentiate, and produce melanin to re-pigment a newly growing hair