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While there are no FDA-approved therapies targeting Lp(a) reduction, sufficient evidence supports ASO and siRNA therapies for specifically lowering Lp(a) concentrations (albeit still in early-stage trials)

Aside from lifestyle modifications, metformin is considered the first-line treatment for glycemic control according to the 2023 American Association of Clinical Endocrinologys T2DM management algorithm

Dietary patterns that support GLP-1 biology may also help people tolerate GLP-1 receptor agonist (GLP-1RA) therapy by reducing gastrointestinal side effects, which are a frequent reason for discontinuation in clinical practice

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