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Oxid Med Cell Longev 2018:5396806 Zhao S-M, Gao H-L, Wang Y-L, Xu Q, Guo C-Y (2017) Attenuation of high glucose-induced rat cardiomyocyte apoptosis by exendin-4 via intervention of HO-1/Nrf-2 and the PI3K/AKT signaling pathway

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These transcription factors regulate the expression of GPER target genes, ultimately promoting the apoptosis of cancer cells [69, 70]

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