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It is considered conditionally essential, with supplementation becoming relevant only in specific circumstances

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DOI: 10.1097/00004850-200303000-00001 Spiering BA, Kraemer WJ, Vingren JL, et al

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Also, more generally, development of non-glutamate drugs for pain and depression has been plagued by failures in advanced human trials

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Given the close relationship between TMAO and CKD, the rapid detection of gut microbiota metabolites, such as TMAO, can better prevent cardiovascular CKD and its associated events (Zhang W

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