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Diarrhea: Occured in 28.3% of patients on semaglutide in the STEP-1 trial, compared to 12.4% in the placebo group

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Shortcomings of Animal Models : While preclinical data can be suggestive, they do not always accurately predict clinical outcomes in humans due to differences in physiology, disease progression, and complex metabolic interactions that cannot be fully replicated in animal models