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The findings that loss of claudin-7 expression induces sloughing of intestinal epithelial cells (claudin-7 KO mice), possibly by disrupting the complex between claudin-1, claudin-7 and 1-integrin, highlights the previously underappreciated roles of TJ proteins in cellmatrix interactions

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Collectively, these mechanisms support the therapeutic potential of GLP-1RAs in preventing and treating SIM ( While GLP-1RAs demonstrate promising metabolic and anti-inflammatory effects, their application in treating sepsis remains limited by insufficient clinical evidence, individual variability, and potential side effects

Talk to your doctor or nurse as soon as possible if you have any new or worsening eye problems