glutathione and chronic kidney disease NRF2 in physiology - Bondi - 2024 Selenium (Se), Blood Glutathione Peroxidases

Given its intimate association with ROS, cell death can be triggered by genetically programmed mechanisms (such as apoptosis, necrosis, and pyroptosis), metabolic dysfunction, including ferroptosis, cuproptosis, oxytosis, disulfidptosis [6] and the recently identified sodium-dependent cell death [7]

Epigenetic mechanisms may also be involved in the development of migraine, and understanding environmentally induced genetic changes associated with this disease may eventually guide the development of therapies capable of reversing these pathophysiological changes in gene function

Effect of mecobalamin on diabetic neuropathies: Beijing Methycobal Clinical Trial Collaborative Group

A major mechanism linking GSH to signal regulation is S-glutathionylation (SSG), a reversible post-translational modification in which GSH forms a mixed disulfide bond with reactive cysteine residues on target proteins