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These may correspond to the intracranial (superior sagittal sinus), portal, and caval hypertension, aortal hypotension, ECG disturbances, brain swelling and lesions, heart dysfunction, lung lesions, liver, and kidney failure, gastrointestinal lesions, widespread arterial and venous thrombosis, venous congestion (i.e., inferior caval vein and superior mesenteric vein), and venous failure (azygos vein) in the occlusion/occlusion-like syndromes [18,19,20,21,22,23,24,25,26,27,28,29,30]

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Like JNK, the activity of ASK1 is low in nonstressed cells due to its sequestration via protein: protein interactions with GSTM1 (GSTM1: ASK1 complex), and/or thioredoxin (Trx:ASK1 complex) (Cho et al ., 2001