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Similarly, recruitment of participants with severe hepatic impairment into the hepatic impairment study was challenging and, despite a third study site being added and the recruitment period being prolonged, it was not possible to complete recruitment of seven participants into the severe hepatic impairment group

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Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Pablo Rivera-Fuentes reports financial support was provided by Swiss National Science Foundation.