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[12] demonstrated a low overall risk of bias, whereas the studies by Giagulli and Graybill [1, 11] were found to have a moderate risk of bias, primarily due to concerns related to outcome measurement and participant selection (Fig

Aldosterone antagonism enhances sodium, chloride, and water excretion, and reduces the excretion of potassium, ammonium, and phosphate

The CCI was modified to exclude kidney disease and late-diabetic complications, as these covariates were separately adjusted for in the statistical analyses

Topical retinoids can also induce erythema, dryness, flaking, and photosensitivity (Rendon and Dryer, 2016