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In CD dog breeds, IVD disease (mainly Hansen type I herniation) typically develops in the cervical (C2-C6) or thoracolumbar (T11-L3) spine at about 37 years of age [5]

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The reduced incretin effect of GIP in diabetic subjects may be due to the down-regulation of GIP receptor expression, which has been found in pancreatic islets of diabetic Zucker rats and reverted following correction of hyperglycemia [35]