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Individuals with Gut Absorption Issues : Conditions like Crohn's disease, celiac disease, or pernicious anemia (an autoimmune condition where the body can't produce intrinsic factor, a protein needed for B12 absorption) can significantly impair B12 uptake

In obese individuals, adipose tissue inflammation results in the secretion of inflammatory cytokines that further promote hepatic inflammation [190]

doi: 10.2147/COPD.S376714 131 JiangCPengMDaiZChenQ

The mechanisms involve linker for activation of T cells family member 2 (LAT2, also known as NTAL and LAB)-mediated calcium mobilization, TGF-, integrin-mediated cell adhesion, platelet-derived growth factor, and Rac family small GTPase 1 (RAC1)/P21 (RAC1) activated kinase 1 (PAK1)/p38/MMP2 signaling (89)