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In animal studies, resmetirom increases the expression of genes involved in fatty acid oxidation ( CPT1A , ACOX1 ), mitochondrial biogenesis ( PPARGC1A ), and cholesterol catabolism ( CYP7A1 ), while reducing levels of lipogenic targets ( SREBP-1c , FASN ) [1921]

These findings open the door for exploring its broader potential in tissue repair and metabolic health

Mitochondrial Function Studies: Analysis of oxidative phosphorylation, respiratory chain function, ATP production, and mitochondrial membrane potential

Recent research suggests that GLP-1 medications like semaglutide and tirzepatide can improve conditions that are affected by obesity, including sleep apnea