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Peripheral neuropathy applications including diabetic neuropathy, chemotherapy-induced neuropathy, and traumatic nerve injuries represent potential indications based on demonstrated nerve regeneration enhancement in animal models

This naturally occurring substance is found in all mammalian tissues, especially striated muscle, and is required in energy metabolism, such as the oxidation of fatty acids, facilitating the aerobic metabolism of carbohydrates, and enhancing the excretion of certain organic acids

This small molecule, dihexa, penetrates the BBB, induces spinogenesis/synaptogenesis at picomolar concentrations [70] , and is slowly cleared from the blood (plasma stability t 1/2 = 335.5 min) [73]

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