In fact, the more significant hemodynamic effects of this agents, conveyed by TGF restoration, led to afferent arteriole vasoconstriction as compared to efferent vasodilation observed with RAS-inhibition ( Pre-clinical studies in genetically modified animal model of T2DM (OLETF rats, Otsuka Long Evans Tokushima fatty rats) have shown high PRA (plasmatic renin activity) levels, without any change in aldosterone levels under dapagliflozin chronic treatment, in accordance with the aforementioned observations of an independent intrarenal RAS ( Moreover, in recent years the use of small interfering RNAs (siRNA), selectively targeting AGT, as a novel approach of interfering with the RAS has shown beneficial cardio- and nephroprotective properties
Butch, A.W., Ahrens, B.D
"People on GLP-1s are prioritizing protein because it's the macronutrient that they need to preserve muscle mass," New Jersey-based registered dietitian Jenna Werner told NBC News, adding that restaurants are using "this weight-loss cultural movement to hop on that train." FAST FOOD GOES GLP-1: SHAKE SHACK JOINS PROTEIN CRAZE WITH NEW OZEMPIC-FRIENDLY MENU The rapid rise in GLP-1 drugs, which suppress appetite and slow digestion, has coincided with changes across chain menus, from scaled-down portions to snack-sized, high-protein options
COVID-19 immunopathology: From acute diseases to chronic sequelae