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doi: 10.1042/bj3410725 142 SierlaM.RahikainenM.SalojrviJ.KangasjrviJ.KangasjrviS

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Through integrated transcriptomic and metabolic analyses, we found that NOTCH1 -mutated cells exhibit a distinct bioenergetic profile, characterized by upregulation of mitochondrial programs, enhanced oxidative phosphorylation, and elevated ROS production, all hallmarks of an active mitochondrial phenotype (Figs