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Initially, a register-based study from Taiwan suggested that the administration of DPP-4 inhibitors could be associated with an increased risk of TC (Tseng, 2016)

We examined the effects of canagliflozin (CANA) on risk of HHF by baseline estimated glomerular filtration rate (eGFR) in patients with T2D and high CV risk and/or chronic kidney disease from the CANVAS Program and CREDENCE

also demonstrated that Asn levels are increased in activated CD8 + T cells and bind to the SRC family tyrosine kinase LCK, assisting in the phosphorylation of LCK at Tyr394 and 505, enhancing LCK activity and T-cell receptor signaling