Genome-wide studies have reported interactions with over 4,000 genes, including those associated with tissue remodelling pathways, stem cell regulatory networks, and metabolic gene programmes
Vial-based protocols require verification of the source, concentration, sterility expectations, and current rules before dose math
Additionally, probenecid may modulate urate binding by plasma proteins and influence uric acid secretion within the renal tubules
To functionally confirm that aggressive TNBC cells undergo ferroptosis, we exposed the ferroptosis-sensitive 4T1, 4T07, D2A1-m1, and D2A1-m2 cells to RSL3 or erastin together with either the radical-trapping antioxidant ferrostatin-1 (Fer-1), the iron chelator agent deferoxamine (DFOM) or an ACSL4 inhibitor (ACSL4i, Fig