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Retatrutide additionally shows a dose-dependent increase in heart rate, attributed to its glucagon-receptor activity, and indirect network meta-analyses flag the highest adverse-event burden among the modern agents for the most potent drugs

Potential Side Effects and Safety Considerations The most common side effects are gastrointestinal nausea, vomiting, and diarrhoea with additional monitoring warranted for pancreatitis, gallbladder disease, heart rate changes, and diabetic retinopathy

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