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In addition to normalizing the intracellular redox state, antioxidants directly influence the regulation of MAPK and transcription factors and can reduce the production of MMPs, restoring their levels to normal (79)

Moreover, while the use of ASNS alone can cause adverse effects such as pancreatitis and thrombosis, its combination with CB-839 effectively mitigates these risks ( 4.3.5 Combination of ammonium metabolism drugs and radiotherapy Excessive ROS production leads to an imbalance between ROS and the cells antioxidant defense, resulting in DNA damage, a key mechanism in radiation therapy-mediated tumor treatment ( Chemical inhibition of key points of glutamine metabolism, such as GLS and MYC, or genetic knockdown of these genes and glutamine transporters, suppresses glutamine decomposition, thereby inhibiting crucial CSC-driving pathways (WNT/-catenin, the oxidative stress response, and the DNA damage response), resulting in CSC depletion both in vitro and in vivo and enhancing tumor radiosensitivity

Mitochondrial diseases: from molecular mechanisms to therapeutic advances

Supplementation with high-dose trans-resveratrol improves ultrafiltration in peritoneal dialysis patients: A prospective, randomized, double-blind study