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However, since lactate is a metabolic byproduct and greater metabolic demand increases lactate production, the remaining muscle cells produce even more lactate than usual due to their increased workload, hastening the accumulation of lactate and exacerbating neuronal destruction and muscular atrophy

Additionally, the ARI outcome was based on maternal self-report of symptoms, which may introduce recall bias

10.3390/pharmaceutics16070886 [DOI] [PMC free article] [PubMed] 91.Domingues I, Yagoubi H, Zhang W, Marotti V, Kambale EK, Vints K, et al