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To address this limitation, various long-acting GLP-1 analogues have been developed, designed to prolong in vivo efficacy and enhance therapeutic potential (Table 1)

The common gastrointestinal side effects of GLP-1 receptor agonists - nausea, vomiting, diarrhea, constipation - are mediated by the drugs effects on the GI tract and brain, which should be the same regardless of whether the semaglutide or tirzepatide was produced by a commercial manufacturer or a compounding pharmacy

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Because less food is consumed, the food you eat becomes even more important as you still need to meet your overall nutrient requirements