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GLP-1: GLP-1(7-36) & GLP(9-36) GLP-1 is an endocrine peptide hormone synthesized in multiple locations including: 1) L-cells located in the intestinal mucosa, 2) -cells found in the pancreatic islet, and 3) central neurons residing in the nucleus of the solitary tract, a region regulating appetite and digestion (D'Alessio, 2016)

For those interested in understanding their genetic predisposition to different weight loss pathways, PlexusDx offers the Precision Peptide Genetic Test ($99 after your first month of treatment), which evaluates 14 pathways including key variants in GLP1R, FTO, GIPR, and MC4R genes

Third, activation of GLP-1 receptors in the central amygdala affects GABAergic neurotransmission, potentially reducing anxiety and stress-related drinking triggers