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These are reported in Supplementary Table 1 and the interactions of the peptide N-termini with the TMD are shown in Fig

Abbreviations ABHD17: /-hydrolase domain 17 ACSL4: Acyl-CoA synthetase family member 4 AMI: Acute myocardial infarction APT1: Palmitoyl acyl transferase 1 ARF6: ADP-ribosylation factor 6 ART: Artemisinin ATF4: Activating transcription factor 4 ATG2: Autophagy - related protein 2 2-BP: 2-bromopalmitate CRC: Colorectal cancer FPN: Iron exporter ferroportin FRDA: Friedreich ataxia GBM: Glioblastoma GC: Gastric cancer GPX4: Glutathione peroxidase 4 GSDMD: Gasdermin D GSSG: Glutathione disulfide GSH: Glutathione GSTP1: Glutathione S-Transferase Pi-1 HCC: Hepatocellular carcinoma HK1: Hexokinase 1 HSCs: Hepatic stellate cells KRAS: Kirsten rat sarcoma viral oncogene homolog LC3: Microtubule-associated protein 1 light chain 3 LDL: Lectin-like oxidized low-density lipoprotein LIP: Labile iron pool LOXs: Lipoxygenases NASH: Non-alcoholic steatohepatitis NBIA: Neurodegeneration with brain iron accumulation NOD2s-R444C: Pathogenic NOD2 short isoform variant NRAS: Neuroblastoma RAS viral oncogene homolog Nrf2: Nuclear factor erythroid 2-related factor 2 Panx2: Pannexin 2 PATs: Palmitoyltransferases PPAR: Peroxisome proliferator-activated receptor gamma PPT1: Palmitoyl protein thioesterase 1 PRDX6: Peroxiredoxin 6 PUFA: Polyunsaturated fatty acid ROS: Reactive oxygen species Scamp1: Secretory carrier membrane protein 1 SCIRI: Spinal cord ischemia-reperfusion injury SKCM: Skin cutaneous melanoma SLC7A11: Recombinant solute carrier family 7, member 11 STEAP1: Six-transmembrane epithelial antigen of the prostate 1 System Xc: Cystine-glutamate antiporter TFR1: Transferrin receptor 1 WIPI4: WD repeat domain phosphoinositide interacting 4 YTHDF3: YTH N6-Methyladenosine RNA Binding Protein F3 ZDHHC: Asp-His-His-Cys References Dixon SJ et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death

One peptide (Tesamorelin) attaches to a pituitary receptor to restore the body's natural, steady rhythm of growth hormone pulses, while the other (Ipamorelin) mimics the 'hunger hormone' to trigger its own separate pulse

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