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Patients should seek urgent medical attention for severe abdominal pain, signs of pancreatitis, jaundice, or symptoms of serious allergic reactions

That depends on how long it takes for your body to adjust to the medication, says Carmen Fong, MD, a double board-certified general and colorectal surgeon and author of Constipation Nation

Interestingly, researchers found that participants who were switched to a placebo (inactive treatment) nearly halfway through regained an average of 14% of their body weight