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Modern research has confirmed that the active components in these drugs (e.g., salidroside and crocin) have anti-hypoxia, anti-inflammatory, and neuroprotective effects, and their compound combinations can significantly alleviate brain edema and reduce the risk of recurrence (Luo et al., 2022a)

Intraperitoneal IV Intravenous J NK c-Jun N-terminal Kinase KDM4C Lysine Demethylase 4C Keap1 Kelch-like ECH-Associated Protein 1 KO Knockout LDL-c Low-Density Lipoprotein Cholesterol LH Luteinizing Hormone LPS Lipopolysaccharide MAPK Mitogen-Activated Protein Kinase MDA Malondialdehyde MMP Matrix Metalloproteinase MOF MetalOrganic Framework MPO Myeloperoxidase mTOR Mammalian Target of Rapamycin NHANES National Health and Nutrition Examination Survey NF-B Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells NQO1 NAD(P)H Quinone Dehydrogenase 1 Nrf2 Nuclear Factor Erythroid 2Related Factor 2 OCSC Ovarian Cancer Stem Cell PCOS Polycystic Ovary Syndrome PEA Palmitoylethanolamide PEA-LUT PalmitoylethanolamideLuteolin POF Premature Ovarian Failure PPAR Peroxisome Proliferator-Activated Receptor Gamma PPP2CA Protein Phosphatase 2 Catalytic Subunit Alpha PR Progesterone Receptor PR-B Progesterone Receptor-B PTEN Phosphatase and Tensin Homolog ROS Reactive Oxygen Species SOD Superoxide Dismutase SNEDDS Self-Nanoemulsifying Drug Delivery System S-SNEDDS Supersaturable Self-Nanoemulsifying Drug Delivery System SERMs Selective Estrogen Receptor Modulators sFlt-1 Soluble Fms-like Tyrosine Kinase-1 SULTs Sulfotransferases TGA Therapeutic Goods Administration TG Triglycerides TC Total Cholesterol TGF- Transforming Growth Factor Beta TLR4 Toll-Like Receptor 4 TNF- Tumor Necrosis Factor Alpha TOX3 TOX High Mobility Group Box Family Member 3 UGTs UDP-Glucuronosyltransferases USA United States of America VEGF Vascular Endothelial Growth Factor YAP Yes-Associated Protein ZO-1 Zonula Occludens-1 References 1 AbdrabouR.SalamaR.El-NagaR.AzabS