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The following figure shows that inflammation caused by hitting your thumb with a hammer, exposure to UV light, radiation, smoking, and air pollution are all sources of free radicals

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2.3.3 Apoptosis induction ORI induces apoptosis or necrosis of tumor cells in a dose-dependent manner by modulating several pathways linked to apoptosis, including the mitogen-activated protein kinase (MAPK) family and phosphoinositide 3-kinase (PI3K)/AKT pathways

(As Vineyard Health is the practice that produced this case series and where I now serve as Chief Medical Officer, I have a direct interest in this work