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To be included in the RWD set, patients needed to have chronic kidney disease as defined by ICD-10 codes N18, N19, or I12, or eGFR 60%) incorporated at least one medication code pertaining to the cardiovascular system (ATC codes beginning with 'C') and at least one code related to diabetes medications (ATC codes beginning with 'A*')

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The rationale: early-phase neuroplasticity benefits from sustained HGF/c-Met signaling, but once synaptic remodeling is initiated, daily pulses are sufficient to maintain the effect