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STUDY DESIGNS SUSTAIN 4: Head-to-head vs Lantus (insulin glargine U-100) 1,9 Study design: 30-week, randomized, open-label, active-controlled, parallel-group, multinational, multicenter trial to evaluate the efficacy and safety of Ozempic injection vs insulin glargine U-100

This further substantiates the potential of therapies targeting the PYY system in the treatment of obesity

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A 2022 study in Diabetes, Obesity and Metabolism showed that NNMTi treatment combined with reduced-calorie diet "promoted dramatic whole-body adiposity and weight loss in diet-induced obese mice, rapidly normalizing" weight parameters