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c of PIH: Acne breakouts Eczema or dermatitis Cuts, burns, or bug bites Aggressive cosmetic treatments (chemical peels, laser, waxing, etc.) Appearance of PIH: Dark spots or patches at the site of injury Can be red, brown, or even purple, depending on skin tone and depth Irregular and spotty, unlike melasmas symmetrical patches Melasma vs PIH: Key Differences When comparing melasma vs post inflammatory hyperpigmentation , the key difference is that melasma is hormonally and sun-driven, while PIH is linked to trauma or irritation of the skin

The maintenance of optimal reduced/oxidized ratios within cell compartments is crucial for healthy cellular redox 45 , and disruption caused by high concentrations of these substances could explain the observed adverse effects on cell viability

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