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Unpredictable pharmacology : The dose-response relationship for both efficacy and safety has not been characterised at very low doses, creating uncertainty about what effectsbeneficial or harmfulmight occur

These adaptions are linked with various complex systemic interactions such as cellular response, oxidative capacity, and regulation of gene expression and protein level, and this could be achieved through various signaling and structural adaptions (Suhr et al., 2013)

Understanding overall safety and risk factors for any compounds you are taking helps differentiate between potential causes

Single-agent bortezomib in previously untreated multiple myeloma: efficacy, characterization of peripheral neuropathy, and molecular correlations with response and neuropathy