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Of particular interest is the synthesis of immunoactive metabolites: short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids (SBAs), polyamines, and emerging mediators such as trimethylamine N-oxide (TMAO) and inosinewhich act as remote immunoregulatory messengers to reprogram immune niches across tissues [20,21,22,23,24]

Unlike stimulant-based diet pills, GLP-1 agents work through physiological hunger pathways, which means the effects persist as long as the medication is maintained and lifestyle changes support the new baseline

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The GLP-1 Legacy is a book designed for this stage, with a foreword by Professor Jane Ogden