4,35 The immediate-release (IR) formulation of exenatide (Byetta , Amylin Pharmaceuticals, San Diego, CA, USA) was first developed in 2005 to treat type 2 diabetes (Table 1)
It is studied in preclinical models of joint and soft-tissue recovery, anti-inflammatory pathway modulation, and multi-pathway tissue repair
[7] As a result, MB is contraindicated in patients with known G6PD deficiency, and screening for this enzyme deficiency is recommended when considering MB therapy, especially in populations where G6PD deficiency is more prevalent
Tirzepatide is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis, as further slowing of gastric emptying could exacerbate symptoms