gastric sleeve and semaglutide Once-weekly administered after laparoscopic gastrectomy: Effects on body weight, glycemic control, measured nutritional metrics in Japanese patients having both obesity and type 2 diabetes Breaking Med

Introduction G protein-coupled receptors are the largest family of membrane proteins targeted by approved drugs ( Obesity is a chronic multifactorial disease ( Glucagon-like peptide-1 receptor (GLP-1R) Processing of the preproglucagon precursor by prohormone convertase 1/3 leads to production of GLP-1, GLP-2, oxyntomodulin, glucagon and glicentin in a tissue-specific manner ( Figure 1 ) ( Figure 1 Oral GLP-1 Although the injectable treatments have reached double digit weight loss, oral therapies are more cost effective and are more likely to achieve long term efficacy through better compliance and combination strategies ( Glucagon receptor (GCGR) GCGR is a family B GPCR activated by glucagon mainly expressed in liver and kidney and, to a lower extent in heart, adipose tissue, pancreas, gastrointestinal tract and other tissues

It activates the GHRH-R receptor in the anterior pituitary gland, stimulating the pulsatile release of GH

They have similar effects, with even greater efficacy in weight-loss

Epithalon also has been shown to benefit retinitis pigmentosa in both mice and humans and stimulate neurogenesis [8, 9]