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Synthetic hormones from contraceptives or hormone replacement therapy alter the hormonal backdrop that influences gastric motility and glucose metabolism, so tolerability may differ from an unmedicated cycle

Cancer history: Growth factor-modulating peptides like Dihexa may warrant avoidance in those with cancer history, though evidence for concern remains theoretical

Additional Cases Reported in the Literature Three published case reports describe patients who followed a recommended fasting protocol 4,5 but had residual food or fluid in their stomach at the time of the procedure

Clinical trials demonstrate semaglutide reduces body weight by 1522% over 68 weeks at therapeutic doses, with consistent results across study populations