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Patutina OA, Gaponova Miroshnichenko SK, Senkova AV et al (2020) Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency

Most claims come from cell studies, not clinical trials.

Importing, possessing, or using TB500 for self-administration may violate customs laws or health regulations, depending on the jurisdiction

This flexibility enabled regulators to tailor safety monitoring based on actual risk profiles observed during drug development, facilitating the approval of drugs like GLP-1R agonists for broader therapeutic use, including in non-diabetic populations with Cardiovascular-Kidney-Metabolic (CKM) Syndrome