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Through this journey, SNAC (N-[8-(2-hydroxybenzoyl)amino] caprylate) was developed, which also led to the development of oral semaglutide and other leading compounds such as 5-CNAC (8-(N-2-hydroxy-5-chloro-benzoyl)-amino-caprylate) and 4-CNAB (N-(4-chlorosalicyloyl)-4-aminobutyrate) (Figure 5)

Metabolic acidosis: This is caused by high acid levels in the blood with symptoms such as rapid breathing, fatigue, or heart rate changes

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Adv Exp Med Biol 595:453470