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In mouse models of DMD, it has been found that IGF1-LR3 and other IGF-1 derivatives are capable of counteracting the negative effects of myostatin to protect muscle cells and prevent apoptosis

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It was evidenced that Western blot analysis of MAPK signaling pathway showed decreased phosphorylation of ERK (pERK/MEK) in cells treated with 10 ng of BPC 157 and in cells treated with the combination of 10 ng/mL of VEGF and 10 ng/mL of BPC 157 in comparison to control cells and VEGF-stimulated cells