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CalBio bought out the founders, thus ending the work on GLP-1 for this small startup

One subsequent analysis has estimated that 7.9 million individuals meet the SELECT trial criteria in the US: Among these individuals, treatment with semaglutide could prevent about 190 000 cardiovascular events in 5 years. If each eligible patient received semaglutide at a retail price of $16 188 per year, the total cost would amount to $127 billion per year. The authors of SELECT noted that: Potentially less costly alternatives for reducing obesity and CVD risk include lifestyle counseling, dietary fasting, and alternative pharmacological weight loss approaches

Clinical trials show diarrhea affects approximately 8-30% of patients depending on the formulation and dose, meaning most patients do not develop this side effect

Phase 2 trial data published in The New England Journal of Medicine (2023) reported up to approximately 24% total body weight reduction over 48 weeks in a dose-dependent manner