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Moreover, GIP has been found to boost glucose uptake by improving insulin sensitivity in adipocytes (176, 177), while tirzepatide has been demonstrated to enhance insulin sensitivity and promote glucose disposal in white adipose tissue in Glp-1r-null mice (178), further supporting a direct effect of GIP on adipose tissues

Patients should seek urgent medical advice for severe abdominal pain, persistent vomiting, or signs of pancreatitis or gallbladder disease

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