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We report on the clinical and molecular characteristics of 20 additional patients with clEDS to expand knowledge and to enable improved management of this rare genetic disorder

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The published research literature has investigated: Lipolysis stimulation (fat breakdown in adipose tissue) Lipogenesis inhibition (reduced new fat cell formation) Receptor-independent activity (no GH receptor engagement) No effect on IGF-1 levels No effect on insulin sensitivity or glucose homeostasis Tesamorelin mechanisms

Yes, but temperature control is the critical constraint