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BMJ Open 9 (10), e031142

From a cost perspective, nanoencapsulation can increase ingredient costs by 2050% depending on carrier material and process energy demand, which may not be feasible for commodity products unless consumer-perceived value justifies the premium (197)

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It should be based on: Long-term results Long-term safety Long-term affordability Long-term quality of life That is exactly why gastric sleeve remains such an important option, even in the GLP-1 era