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[DOI] [PMC free article] [PubMed] [Google Scholar] 83.Blanca A.J., Ruiz-Armenta M.V., Zambrano S., Miguel-Carrasco J.L., Arias J.L., Arevalo M., Mate A., Aramburu O., Vazquez C.M

Bulk Pricing One vial-size format is stocked: 10 mg total

Decorin upregulation represents a fourth mechanism: decorin is a proteoglycan that organizes collagen fibril assembly and suppresses TGF-beta-mediated fibrosis, so its upregulation by GHK-Cu may support organized tissue repair with reduced scar formation

Key Highlights AOD9604 activates lipolytic pathways through beta-3 adrenergic receptor upregulation and cAMP-PKA-HSL cascade activation in adipocytes The peptide inhibits acetyl-CoA carboxylase to suppress lipogenesis while promoting fatty acid oxidation in laboratory models Research confirms no IGF-1 stimulation or glucose metabolism disruption, distinguishing it from full-length growth hormone Cartilage studies show proteoglycan synthesis enhancement and improved tissue structure in osteoarthritis animal models What is AOD9604