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The overexpression of metrnl induces the expression of SIRT3 by promoting the expression of transcriptional activator PGC-1, increasing the expression level of UCP1 and the activation of AMPK in PA-treated RTECs to accelerate mitochondrial autophagy, maintain mitochondrial homeostasis, and alleviate lipid accumulation (a thermogenic factor) (Zhou et al., 2023)

Catalpol, a naturally derived compound, has emerged as a potent agent with significant protective effects on damaged tissues and organs (Feng et al., 2019

The attrition bias and reporting bias were both low as no study was selectively reporting or with incomplete outcome data

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