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3 In B12 deficiency, methylmalonic acid (MMA) can accumulate, and it is thought that elevated MMA, alongside elevated homocysteine, contributes to damage of the myelin sheath (which protects nerve cells and speeds up nerve transmission), which can cause irreversible neurological problems
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doi: 10.1007/s11154-021-09669-7 83 HirschIB
Within the mitochondriathe powerhouses of our cellsCoA is required to initiate the Krebs cycle (also known as the citric acid cycle), which is the primary pathway the body uses to generate adenosine triphosphate (ATP), our cellular energy currency
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