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The 6-pyruvoyltetrahydropterin synthase enzyme is encoded by the PTS gene which is located on chromosome 11q23.1 and is composed of 6 exons that encode a 145 amino acid protein

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A phase 2, multicenter, randomized, double-blind, placebo-controlled trial in the United States assessed the efficacy and safety of retatrutide in 338 adults aged 1875 years without diabetes but with obesity or overweight plus 1 weight-related condition for 48 weeks