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From the normal physiology of this axis, it is possible to understand the consequences of various genetic defects and disorders that affect its regulation and function

In this way, the asparagine residue creates a negative redox potential within the active site, which is required for the catalytic reaction, as the imidazolate strengthens the metal-histidine bond, which in turn stabilizes the metal in its higher/highest oxidation state

Impairment of mitochondrial calcium buffering links mutations in C9ORF72 and TARDBP in iPS-derived motor neurons from patients with ALS/FTD

It was first identified in 1973 in human plasma and later found to be critical for wound healing and tissue remodeling