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Upadacitinib as induction and maintenance therapy for moderately to severely active ulcerative colitis: results from three phase 3, multicentre, double-blind, randomised trials

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In branched amino acid catabolism, the branched-chain -ketoacid dehydrogenase complex requires TPP to convert branched-chain -ketoacids into branched-chain acyl-CoA, which is then converted into acetyl-CoA and enters the citric acid cycle

For instance, one placebo-controlled clinical trial demonstrated significant improvements in bench press and leg lifting volume along with beneficial changes in total antioxidant capacity in men who supplemented with carnitine daily but not around their workout for nine weeks (6)