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304 Elevated concentrations of insulin-like growth factor-binding protein-7 (IGFBP7) are recognized to facilitate cardiac senescence, hindering DNA repair and resulting in ROS production, thus expediting the onset of HF

Since the ultimate goal of the project was to produce a clinically relevant molecule that could be delivered peripherally but still exhibit pro-cognitive/anti-dementia activity, the effectiveness of both the intraperitoneal and oral delivery routes of dihexa administration were determined using the scopolamine model